Noob questions

So before I start. Just know I'm a complete noob when it comes to modding.
Is it possible to have different mods for different saves? Like say i wanted to do a playthough with Things to do in Steelport and another playthrough with a completely different mod.

Also I wanna use mod(s) that add more gangs. Are there any that work with Things to do in Steelport? Or that are easy to.. merge or whatever for a noob.
 
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