For save games that uses mods which require a new save game, is it possible to add new mods without breaking the save?

I want to add new mods like SRTT style third-person camera, textures packs, etc. However, the save game I want to add it to has ImpulseOfSword2007's SR2 Complete Combat Overhaul mod installed, which requires a new save game after install to prevent mod-related bugs.

If I generate a new patch with that plus other mods, would it be considered as a new different install and break my save? Or would it simply update the older mod without any issues?
 
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