I can't speak for other than what I'm using.
I"m having no issues with the 'old' mods I use that are still xtbl edit based.
The ones that you would stuff in the game executable directory.
However,that number has dwindled greatly from the 10 or so I had been using to
just 2 or so xtbl based edits. Most of what I'm using now is mods that were incorporated
into the Gentlemen of Saints Row compilation.
Any of the mods that would go in the pc/cache dir though, that would be broken unless updated.
Pretty sure anyway. Not a issue as long as your using the latest GoSR pack.
Of the 'old' ones I'm still using dummybumps xtbl mod to alter body geometry slider effects and
the Murder and Porn (I think that was the name or something like that) mod that allows a real nude texture,
and a xtble edit that allows for a taller character than normal.
The latter is now part of the GoSR pack but I wanted taller than even Brute scale which is in the current pack.
Some of those mods date back to December.